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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Transapical transcatheter mitral valve implantation of the Tiara bio-prosthesis ： ウィキペディア英語版 Transapical transcatheter mitral valve implantation of the Tiara bio-prosthesis The Neovasc Tiara is a bioprosthetic mitral valve with a novel transcatheter implantation approach to minimize complications associated with conventional mitral valve replacement or repair.〔〔〔 Approximately half of patients with severe symptomatic mitral regurgitation are denied surgery due to factors such as advanced age, co-morbidity, or decreased left ventricular ejection fraction.〔〔 The less invasive, transapical transcatheter approach used with the Tiara mitral valve may be a promising future alternative.〔〔〔 The Tiara mitral valve is currently undergoing human clinical trials, the first of which was successfully performed on January 30, 2014, at St. Paul’s hospital in Vancouver, BC.〔 Since the trials are very recent, the long-term effects of this mitral valve bio-prosthesis in humans are currently unknown. == Valve Properties == The Tiara consists of a self-expanding metal alloy frame with three bovine pericardial tissue leaflets.〔〔 The leaflets are cross-linked and mounted on the frame, which is then crimped onto a 32F flexible catheter for implantation.〔 The complex, asymmetrical anatomical structure of the mitral valve poses a challenge for prosthetic mitral valve fabrication.〔〔 The Tiara’s D-shaped frame matches the natural shape of the mitral annulus, allowing for accommodation of the left ventricular outflow tract (LVOT).〔〔 The straight portion of the valve’s frame faces the LVOT allowing blood to flow, uninterrupted, into the aorta and ultimately into systemic circulation.〔〔 The mitral valve must be securely anchored to withstand the pressure gradients that occur between the left atrium and ventricle throughout the cardiac cycle.〔〔 The Tiara has three ventricular anchors, which are secured behind the anterior and posterior leaflets of the native valve, preventing retrograde displacement (into the left atrium) during systole.〔〔 Paravalvular leak is prevented by the Tiara’s atrial skirt structure.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Transapical transcatheter mitral valve implantation of the Tiara bio-prosthesis」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.